Opioids are powerful drugs with a high risk for dependency. Taken in high doses, and/or with other substances can result in respiratory distress and death. Common Questions and Answers about Can you take oxycodone and ibuprofen together Yes, you can. The generally accepted maximum daily dose is 4 grams. In long term care 3 grams is often used as a safe cutoff. The manufacturer of the brand Tylenol recommends a 3 gram limit, likely due to patients not being aware of the acetaminophen found in so many OTC mixed products. You can indeed take both of these medications at the same time, and in fact your doctor may recommend that you do so. The drug combination hydrocodone/ibuprofen (INNs, trade name Vicoprofen) is an analgesic medication used in short-term therapy to relieve severe pain. Vicoprofen combines the analgesic and antitussive properties of hydrocodone with the analgesic, anti-inflammatory, and antipyretic properties of ibuprofen. In contrast to hydrocodone. Oxycodone comes as a solution (liquid), a concentrated solution, a tablet, a capsule, an extended-release (long-acting) tablet (Oxycontin) and an extended-release capsule (Xtampza ER) to take by mouth. I have a friend that is an extreme opioid abuser. She is wanting to get started on Suboxone treatment for this addiction yet the problem is is that she has chronic pain from arthritis and other health problems. Hey Alan, You can take oxycodone with the ibuprofen at the same time if you want. In fact, there is one formula of oxycodone that is mixed with ibuprofen rather than acetominophen which is what the APAP is. by Neil Bauman, Ph.D. A lady wrote: I took 800 mg of Ibuprofen for pain relief for dental work and found I got tinnitus after that. As soon as I stopped taking the Ibuprofen, which was almost immediately following getting the side effect, the tinnitus stopped as well. Doctors give trusted answers on uses, effects, side-effects, and cautions: Dr. Le on is it okay to take advil and percocet together: This combination may be very effective on a short-term basis, such as treating pain due to surgery or fracture.